Eulexin (flutamide) is a non-steroidal anti-androgen (NSAA) medication used to treat prostate cancer. Eulexin works by binding to androgen receptors, preventing androgens from binding to these receptors. This prevents androgens from stimulating the growth of prostate cancer cells. Eulexin is typically used in combination with a GnRH agonist or surgical castration. Eulexin is available in generic form. Generic Eulexin is covered by most Medicare and insurance plans. Eulexin may also be used for purposes not listed in this medication guide. Important Information You should not use Eulexin if you are allergic to flutamide. Before taking this medicine You should not use Eulexin if you are allergic to flutamide. To make sure Eulexin is safe for you, tell your doctor if you have: liver disease; kidney disease; diabetes; a history of heart disease or heart attack; a history of stroke; high blood pressure; a history of blood clots; if you are also taking a blood thinner (warfarin, Coumadin, Jantoven); if you are also taking an insulin or oral diabetes medication; if you are also taking a "water pill" (diuretic); or if you have ever had an allergic reaction to another anti-androgen medication. Eulexin can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using this medicine. Eulexin is not approved for use by anyone younger than 18 years old. How should I take Eulexin? Take Eulexin exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Eulexin is usually taken 3 times per day with meals. You may need to take Eulexin on a full or empty stomach. Follow your doctor's instructions. Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time. To take the flutamide capsule with food, open the capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow right away without chewing. Do not save the mixture for later use. Do not skip doses or stop using Eulexin without first talking to your doctor. Stopping suddenly may make your condition worse. If you need surgery, tell the surgeon ahead of time that you are using Eulexin. You may need to stop using the medicine for a short time. Store at room temperature away from moisture, heat, and light. Eulexin dosing information Usual Adult Dose for Prostate Cancer: 250 mg orally 3 times a day with meals Usual Geriatric Dose for Prostate Cancer: Initial dose: 250 mg orally 3 times a day with meals What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, diarrhea, and stomach pain. What should I avoid while taking Eulexin? Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using Eulexin. Avoid eating grapefruit or drinking grapefruit juice while you are using this medicine. Eulexin side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: jaundice (yellowing of the skin or eyes); dark urine, clay-colored stools; pain in your side or lower back; little or no urinating; swelling, rapid weight gain; shortness of breath; a light-headed feeling, like you might pass out; high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor; low blood sugar - headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling jittery; signs of a blood clot - sudden vision loss, ringing in your ears, dizziness, confusion, muscle weakness, cold feeling in your arm or leg, pain spreading to your jaw or shoulder, and shortness of breath; signs of liver problems - loss of appetite, upper stomach pain (that may spread to your back), nausea and vomiting, dark urine, jaundice (yellowing of the skin or eyes); signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; or signs of a blood clot in your lung - chest pain, sudden cough, wheezing, rapid breathing, coughing up blood. Common Eulexin side effects may include: mild nausea, vomiting, diarrhea, constipation; stomach pain, bloating; headache, drowsiness; increased sweating; hot flashes; decreased sex drive, impotence, or difficulty having an orgasm; swelling in your hands or feet; or weight gain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What other drugs will affect Eulexin? Tell your doctor about all other medications you use, especially: any other cancer medications; a blood thinner (warfarin, Coumadin, Jantoven); insulin or oral diabetes medications; a "water pill" (diuretic); heart or blood pressure medication; or seizure medication. This list is not complete. Other drugs may affect Eulexin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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